An Oncologist's Ultimate Guide to Lung Cancer Treatment in Singapore (2019)

An Oncologist's Ultimate Guide to Lung Cancer Treatment in Singapore (2019) undefined
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Lung cancer is the 2nd most common cancer in Singaporean men. In women, it is the 3rd most common. Cancer happens when abnormal cells grow into tumours. When this affects the lungs, it can hinder breathing functions.

A cancer diagnosis can be scary. The good news is that there are now various new treatments that can greatly increase survival. It is most important to get a treatment that is individualised to your condition.

In this article, I will be discussing everything about lung cancer. Read on to find out more about its risk factors, diagnosis, and new treatment methods!

What is lung cancer?

lung-cancer

Lung cancer occurs when there is abnormal growth in the cells lining the airway of your lungs. It can start from any part of the lungs, both left and right.

There are 2 different types of lung cancer: [1]

  • Non-small cell lung cancers (NSCLC)

    The majority of lung cancers are either adenocarcinoma or squamous cell carcinoma. They account for around 85% of all lung cancers. Both are grouped under NSCLC as they tend to have similar treatment routes.

  • Small cell lung cancers (SCLC)

    This is rare but is more aggressive. On top of that, it spreads much faster and tends to be diagnosed only after it has spread. For these cases, we will need to use chemotherapy and radiation to manage the symptoms. Unfortunately, they also have a high recurrence rate.

In this article, I am going to focus only on NSCLC. They are much more common and also have a higher chance of recovery.

What are the symptoms of lung cancer?

symptoms-lung-cancer

When the cancer is small, it rarely causes any symptoms. This is why most of my patients are diagnosed only after the cancer has developed into a later stage.

There are some common symptoms such as [2]

  • Persistent cough
  • Breathlessness
  • Pain around the chest or other body parts

You may be confused about why pain in other body parts can be a symptom of lung cancer.

I had a young patient who came to me for hip pain. I found a crack in her hip bones, even though there was no history of trauma. On top of that, further tests found that she had lesions in her lungs and brain. She was eventually diagnosed with advanced-stage lung cancer without lung symptoms.

To avoid a late diagnosis, I would advise that you seek medical attention if you see any new symptoms. This is especially true for any persistent pains.

What causes lung cancer?

causes-lung-cancer

Based on my experience and also data from various research, the leading risk factors include: [3]

  • Smoking
  • Second-hand smoke
  • Environmental pollution

You may have heard that lung cancer is more common in males. Research has also found that to be true. This is due to a difference in lifestyle with males being more prone to the risk factors mentioned above [4].

Interestingly, I have seen an increase in lung cancer cases in those who do not smoke. There is also an increased incidence in women. These cases are most likely due to gene mutations that cause cells to grow uncontrollably.

“I am still young, don’t worry!”

Most of my patients are indeed above 50 years old. However, that is not to say that young adults have no risk of developing lung cancer. 2-5% of lung cancer patients are actually younger than 40 years old [5].

On top of that, your current lifestyle may affect and increase your risk of developing the disease. Even though lung cancer usually develops much later, most cases are related to an early onset of smoking [6].

Regardless of age, I highly recommend that you stop smoking. It is not only about lung cancer, but smokers are also at much higher risk of developing hundreds of diseases.

How is lung cancer diagnosed?

If you see symptoms of lung cancer, consult a doctor immediately.

Firstly, I will send patients for a scan. It can be a chest X-ray, CT scan, or a PET-CT scan. The prices differ between the types of tests and the regions tested for.

Type of testCost
Chest X-ray$45 - 120
CT scan$600 - 1800
PET-CT scan$2000 - 4000

 

For cancer patients, you can use up to $600 each year from MediSave to pay for the different types of scans.

To confirm the diagnosis, I will also send you for a biopsy. This is done in 2 different ways:

  • Under CT guidance OR
  • Via bronchoscopy if the lump is deeper in the lungs and closer to the main airways.

Depending on the type, the biopsy will cost between $2500 – 4000 in private hospitals.

Some patients have asked me if it is possible to diagnose cancer just from the scans. The answer to that is simply 'No’. The biopsy is important because it can show the exact cell type. I can determine which treatment is suitable for you only after that is clearly defined.

In addition to diagnosis and treatment, the biopsy results will also be needed for your insurance claims.

How are lung cancer patients treated in Singapore?

treatment-lung-cancer

As mentioned earlier, the first step is to confirm the diagnosis. The treatment will depend on the stage of the cancer. Before that, let me first explain the difference between grading and staging.

Grading depends on how aggressive the cancer cells are. This is based on how the cells look under a microscope.

On the other hand, staging refers to the extent of spread. This is whether the cancer has spread to other parts of the body. With that, the stage of your cancer dictates the choice of treatment [7].

There are a few different modalities and the choice will depend on your condition. Most importantly, quite a few of my patients will also have to undergo a combination of treatments. These may include:

  • Surgery
  • Chemotherapy
  • Radiation
  • Targeted therapy
  • Immunotherapy

Surgery

surgery-lung-cancer

I usually recommend surgery only for those whose cancer is still localised. This is to say that the cancer is still in the very early stage and it has not spread to other parts of the body.

Depending on the size of the cancer, there are two methods of surgery:

  • Keyhole
  • Open chest wall

On top of that, there are different types of surgery depending on what is removed. That is:

  • Wedge resection: smaller part of the lung when the cancer is small enough
  • Lobectomy: a whole lobe of a lung
  • Pneumonectomy: a whole side of the lung

During the surgery, I will also remove the surrounding lymph nodes. This is to detect microscopic spreads that might be missed in the scans before the surgery.

I will also send the removed tumour for microscopic examination. This is to make sure that the margins are all cleared and no cancer cells are left behind. The result of this will determine if you need to take chemotherapy.

Chemotherapy

chemotherapy-lung-cancer

I had patients who asked me, “Why do I still need chemo when I have already gotten surgery?”

It is because there is currently no way to guarantee that there are no more cancer cells in the body. I administer chemotherapy to hopefully kill whatever cancer that is still there. That said, not everyone needs it. You should consult an oncologist to see which treatment is necessary. It will depend on your condition and also the final report after the surgery.

Indications that might show that you need chemotherapy include:

  • Larger tumour size
  • Traces of spreading to lymph nodes

Radiotherapy

radiotherapy-lung-cancer

For a locally advanced tumour with spreading to nodes, surgery is not suitable. This is especially if the spread can be found in scans as it shows that the spread is quite rampant.

Instead, I would recommend getting chemotherapy and radiotherapy concurrently. Chemotherapy uses drugs to kill cancer cells. On the other hand, radiotherapy uses a high dose of radiation. It could kill or, at least, slow down the growth of cancer cells [8].

At this stage, the disease is still curable. In addition to that, there are also new treatments that can help you get a full recovery.

Targeted therapies

benefits-of-targeted-therapies-lung-cancer

These are drugs that target specific gene mutations found in lung cancer. Consider these mutations as "switches" that "turn on" cancer growth. The drugs help block these mutations. With that, we are essentially turning off the "switches" that cause the cancer cells to grow uncontrollably.

Not all cancers have these gene mutations. This is why it is important to get a complete test to see whether this treatment is suitable for you. If it is, there are some advantages:

  • The rash and diarrhoea side effects are easier to manage as compared to other treatments.
  • They often come in pill form and thus very convenient.

Technologies have not only improved treatment options. Increasingly, a blood test can also detect these mutations. That said, this is still uncommon and may not be as sensitive as the older methods. You can ask your oncologist to see if you can take this option.

Immunotherapy

immunotherapy-lung-cancer

When used together with chemoradiation in stage 3 lung cancer, immunotherapy could reduce future recurrences. With that, your chance of survival also increases.

Immunotherapy is also a very promising treatment for stage 4 lung cancer patients. While it is not for all patients, the ones that respond to it usually do very well. It is now possible to say that some patients appear to be in prolonged remission while undergoing immunotherapy [9]. This is to say that all signs of cancer are paused during the treatment process.

Immunotherapy works by boosting the body’s natural immune system. It helps your body fight against the cancer cells. The type you need will depend on your condition. I will use the results of your PD-L1 immunohistochemistry testing to determine the type that is most suitable for you.

A cancer diagnosis is scary. But as you can see, there are various treatments available. With that and the ongoing research, I am sure that there is a treatment that can help you manage the condition.

In other words, it is now very common to send the lung biopsy for multiple testing. It is no longer just to determine the stage. Detailed data on your condition will help doctors choose the most appropriate treatment specifically for you. No two cancers are the same. With what is available now, treatment of lung cancer is personalized to each individual.

How does a personalised treatment for lung cancer work?

personalised-treatment-lung-cancer

Let me give you an example of one of my patients. At first, she presented water in her chest from lung cancer. Further tests found a gene mutation to be the main cause of the cancer. I prescribed targeted therapy, in the form of pills, for her treatment.

Within a month her symptoms improved. As mentioned earlier, targeted therapy works very well for those with a gene mutation. She managed to stay on the pills for 2 years before resistance was apparent. This is to say that the cancer started growing again after the initial period of shrinkage while on the treatment.

I sent her for another test to detect further gene mutations. Lo and behold, a different gene mutation was found. For that, I prescribed another pill and this kept her disease controlled for another 2 years. She just recently started on chemotherapy. This is after 4 years of good control with just pills.

This example shows how various treatment methods can work depending on your condition. It also shows that the treatment depends on your diagnosis! If you suspect lung cancer, please get a detailed test as soon as possible. 

Targeted therapy could be a new option that would allow better care for cancer patients. That is a treatment with greater comfort and fewer side effects.

The different types of treatment increase the chance of survival

I have another elderly patient who initially presented coughing of blood. He ended up in the ICU and was initially treated with chemotherapy. It was evident that his lung cancer was not responding to the treatment.

I changed his treatment route to immunotherapy. This was back in 2015 when the method was first made available in Singapore. The lung cancer responded well with this treatment and his latest scan showed that the cancer may not be there anymore.

What should I do if I think my loved one has lung cancer?

love-ones-lung-cancer

If you see any symptoms, do consult a doctor immediately. As with other cancers, early diagnosis will greatly improve your chances of a full recovery.

Lung cancer treatment has come a long way and the recent developments have improved the survival of many patients. More importantly, survival is prolonged in a meaningful way.

I always tell my patients that it is possible to get the strongest treatment available that will greatly shrink the cancer. That said, there is no meaning to this if the side effects cause the patients to be bound to a bed for the rest of their lives.

I always take the time to discuss the details of the disease with the patient and their caregivers. It is very important for everyone involved to have the same understanding and expectations. That is throughout the whole process from diagnosis to treatment and also future follow-ups.

Also read: Cancer Caregivers: The Greatest Form Of Support Through The Cancer Journey

To patients, what matters most is empathy and the independence to make their own decisions. It is important to let patients decide the direction they want to take through their cancer journey. My role as an oncologist is to diagnose and present all the possible treatment methods. With all that is available in Singapore, I am sure that there is a treatment that will help you manage the condition.

Gone are the days where we would tell patients that there is no treatment available and that their time is limited. The advent of new therapies has truly turned one of the deadliest cancers to something that is more treatable.

Is lung cancer treatment Medisave-claimable?

As mentioned earlier, there are various treatment methods available in Singapore. Problem is, lung cancer treatment can be quite expensive.

For that, the government has various subsidies to help you pay for the treatment:

  • MediSave
    • Surgery: up to $5000 depending on the type
    • Chemotherapy (and immunotherapy): up to $1200 per month
    • Outpatient radiotherapy: up to $80 (external) or up to $360 (internal) per treatment
  • MediShield is the basic life insurance operated by CPF. It is aimed to subsidise your treatment fees so you have to use less of your MediSave.
  • Medifund is the safety net set for patients who cannot afford treatment even after MediSave and MediShield. For more information, click here.
  • Medication Assistance Fund is available to pay for certain drugs that are not in the Standard Drug List. It depends on your prescription, so do ask your doctor.

Prevention is still better

preventing-lung-cancer

Treatments are available but there is no complete guarantee for a full recovery. Cancer may reoccur and the treatment itself is a long process that can be very tiring.

Regardless of the continuous improvements in treatments, preventing lung cancer is still the better option. These are some ways to prevent lung cancer:

  • Stop smoking
  • Avoid second-hand smoke
    • Do not allow smoking around your house
    • Use N95 respirator mask in smoke-prone public places
  • Ensure workplace safety by following the correct procedures when handling chemicals containing carcinogens

I wrote this article so that everyone may be more aware of their health. On top of that, I want to emphasise on all treatment methods that are available in Singapore, both old and new.

Prevention is still number one, next comes early diagnosis. Regardless, there are various treatments that can be individualised, specific to your needs. If you see any prolonged and unexplainable symptoms, do visit a doctor immediately!


Get treatment quote for Lung Cancer

Dr Ooi Wei Seong is an oncologist at International Cancer Specialists. His main interest lies in the treatment and management of lung, breast, and colon cancers. On top of his clinical work, he is also an active speaker, tutor, and researcher who has participated in multiple clinical trials.

Read more from Dr Ooi Wei Seong in his Q&A here. 

 

Would you like to ask any related health questions?

You can Ask A Doctor right away, or view the complete list of DxD Sessions.

References:

1. The American Cancer Society medical and editorial content team. What is Lung Cancer. Cancer.org. Published 2019. Accessed October 14, 2019.

2. Lung cancer - Symptoms and causes. Mayo Clinic. Published 2019. Accessed October 17, 2019.

3. Subramanian J, Govindan R. Lung Cancer in Never Smokers: A Review. Journal of Clinical Oncology. Published 2016. Accessed October 16, 2019.

4. Barrera R, Morales Fuentes J. Lung cancer in women. Lung Cancer: Targets and Therapy. December 2012:79. doi:10.2147/lctt.s37319

5. Kozielski J, Kaczmarczyk G, Porębska I, Szmygin-Milanowska K, Gołecki M. Lung cancer in patients under the age of 40 years. Współczesna Onkologia. 2012;5:413-415. doi:10.5114/wo.2012.31770

6. Hymowitz N. Cigarette Smoking and Lung Cancer: Pediatric Roots. Lung Cancer International. 2012;2012:1-7. doi:10.1155/2012/790841

7. LoCicero R, Stump-Sutliff K. Grading and Staging of Cancer - Health Encyclopedia. University of Rochester Medical Center. Accessed October 18, 2019.

8. Radiation Therapy for Cancer. National Cancer Institute. Published January 8, 2019. Accessed October 18, 2019.

9. Jung CY, Antonia SJ. Tumor Immunology and Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer. Tuberculosis and respiratory diseases. 2018;81(1):29-41. doi:10.4046/trd.2017.0120

332 views 5 Nov 2019 Medically reviewed by Dr Ooi Wei Seong on 8 Nov 2019.
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