For someone with depression, what are the next steps if counselling and SSRIs have not helped me at all?

Doctor's Answers 1

It must be quite exasperating for you to realise that your mood has not improved despite treatment with counselling and SSRIs (serotonin sepcific reuptake inhibitors, antidepressants). May I offer a number of suggestions:

Firstly, to get your condition re-evaluated and rediagnosed. Sometimes there are many other issues that complicate a depressive disorder, like:

  1. chronic pain,
  2. anxiety and
  3. poor sleep.

Oftentimes for a depressive disorder, we also need to figure out why a person became depressed. For instance, it could be some relationship issues that perpetuate the depression and hence when planning interventions, we need to figure out how to resolve the relationship difficulty.

Secondly, to find out what is covered during counselling. Supportive counselling may not be the best form of psychological intervention in depressive disorders. What the evidence shows is that therapy using cognitive behavioural therapy (CBT) and interpersonal psychotherapy (IPT) may be more effective.

CBT involves looking at:

  • a person"s negative thoughts,
  • getting the individual to learn to monitor the negative thoughts and
  • to modify them.

IPT looks at the challenges in the interpersonal arena like:

  • grief,
  • life transition issues,
  • disputes and
  • social isolation/ lack of social skills.

Thirdly, to consider the dose and duration of SSRIs used. If the dosage is too low, the antidepressant may not be effective. Most SSRIs will take about 4 to 6 weeks to work. If SSRIs do not work, then I will consider using antidepressant from another family or class, like SNRI (which works on norepinephrine receptors as well), mirtazapine, agomelatine and bupropion. There are many antidepressants available in the country so your doctor will be able to find the right antidepressant for you.

Next, is to consider augmentation with aripiprazole, which can be used as a mood stabiliser.

Lastly, you can consider in-patient evaluation and treatment. Sometimes, the home situation or problems at work can be the factor that maintains depression, so a short respite from home and work may help.

Similar Questions

Are there any alternatives like psychotherapy that are able to completely replace medication for anxiety and depression?

Thank you for asking this question for the benefit of everyone. It sounds that you are having a tough time, and its double whammy when the treatment gives you unbearable side effects. Unfortunately in medicine, it is often times a zero sum game. Everything seems to have its "costs" and "benefits". Fortunately for you, there are alternatives, like psychotherapy or more commonly known as talk therapy. The good side is that if it works for you, the effect is equivalent to medications, and the effects lasts way longer than medications.

Photo of Dr Paul Ang

Answered By

Dr Paul Ang

General Practitioner

Should I stop taking anti-depressants?

Thank you for sharing your story with us. It appears to me you may have eating disorder with co-morbid depression. Both conditions can be aggravated by stress and both need to be treated. It will be good if you can carefully recall all the treatments that you have received over the years and write down all down. If you have been admitted to hospital, you can also refer to the discharge summaries that you have received from the hospital. You can create two columns, 1 for the type of treatment (including medication) and the other for the response that you have following that treatment modality.

Photo of Dr Beng Yeong Ng

Answered By

Dr Beng Yeong Ng

Psychiatrist

Ask any health question for free

I’m not so sure about a procedure...

Ask Icon Ask a Question

Join Human

Sign up now for a free Human account to get answers from specialists in Singapore.

Sign Up

Get The Pill

Be healthier with our Bite-sized health news straight in your inbox