If you have been trying to conceive but have been unsuccessful for more than 1 year despite regular intercourse, then this means that you and your wife are experiencing infertility issues already.
You should seek a detailed consultation with a gynaecologist to help find a cause, if there is any, and to then start the appropriate fertility treatments which range from oral ovulation medication to SOIUI (superovulation intrauterine insemination) to IVF (in-vitro fertilisation).
If your wife is 40 and above and both of you have been unsuccessful conceiving for at least 6 months, then you should seek help now rather than after 1 year as time is not in your favour. This is because background fertility rate decreases by 1% for every year that a woman is not pregnant after the age of 35 years old.