Chat with us?
Open Chat
You can ask us anything in real-time in our Live Chat!
Open Chat

Request answers from expert doctors:





How long does Hep B vaccination protection last for, and what causes it to run out?

Gastroenterology Health & Fitness Vaccination
DOCTOR’S ANSWER (1)

Hi Mr Kon

Hepatitis B vaccination uses dead or inactivated Hepatitis B viruses to trigger the immune system to mount a response against it, and in doing so, producing immunity against the virus. It triggers two types of responses:

1. Humeral Response (measured by the antibody level) as well as the

2. Cellular Response (not measurable with any blood tests).

When a vaccine is introduced, most patient will mount a response and produce antibodies. Slowly, the antibody levels will decrease (usual recommendation is to check the levels after 5 years).

When the 5 years is up, and if the antibody level has dropped to below the acceptable levels (usually 10 mIU/mL), then you'll need a single booster dose to boost up your antibody levels again. There is no reason for the decline in antibody levels, it just naturally goes down over time.

In recent years, there are many specialists who believe that even though the antibody levels dropped to zero, the Cellular Response will remain for life, and you will not need a booster dose, as long as you had proven to have a positive antibody level at a certain point in your life.

These specialists will not recommend a booster dose even if your antibody levels have dropped to zero. Most doctors in Singapore will recommend a booster dose though.

However, in your question, you did not specify how long was the antibody test taken after the initial vaccination, and was there ever a positive antibody response for your children.

IF there was never a positive antibody test, we have to consider another possibility of your children being a non-responder, or in the worse case scenario, there is a very small possibility of being infected with a rare Pre-S mutant strain of the Hepatitis B virus. (This is a very rare scenario, and hence most doctors will not scare their patients unnecessarily, but since this platform is the internet, I have to list out possible scenarios).

To fully access the possibilities, kindly see your doctor for further assessment and testing, or you can consult a hepatologist (liver specialist)

Cheers!


Dr Seah Heap Yong
MBBS, Dip Geriatric Med, Dip Acup

Shenton Family Medical Clinic (Yishun)

Shenton Family Medical Clinic (Yishun)

160, Yishun Street 11, #01-200, Singapore 760160


765 views 15 Oct 2018
Not the answer you're looking for? Browse other answers tagged Gastroenterology Health & Fitness Vaccination or ask your own question now FOR FREE.
Consult Doctors. FREE.
Real Doctors, Expert Answers
Connect with Facebook Connect with Google For Doctors
By creating an account, you are indicating that you have read and accepted the DoctorxDentist Terms of Use.
Consult Doctors. FREE.
Real Doctors, Expert Answers
By creating an account, you are indicating that you have read and accepted the DoctorxDentist Terms of Use.
Registration Progress
Step 1: Indicate Topics of Interests
Step 2: Follow Relevant Doctors
Complete!
What are your interests?
Please select at least 3 interests.
NEXT
NEXT
Registration Progress
Step 1: Indicate Topics of doctors
Step 2: Follow Relevant Doctors
Complete!
Follow your favourite doctors
We found some doctors you may like. Click continue to follow them.
CONTINUE
CONTINUE
Consult Doctors. FREE.
Real Doctors, Expert Answers
Continue with Facebook Continue with Google

or

Disclaimer: Any answers provided are for general informational purposes only and is not a substitute for professional medical advice. If you think you may have a medical emergency, call your doctor immediately. Always seek the advice of your doctor before starting or changing treatment.

Continue with Facebook Continue with Google

Disclaimer: Any answers provided are for general informational purposes only and is not a substitute for professional medical advice. If you think you may have a medical emergency, call your doctor immediately. Always seek the advice of your doctor before starting or changing treatment.

YOUR QUESTION HAS BEEN

SUCCESSFULLY SUBMITTED.

YOUR QUESTION

HAS BEEN

SUCCESSFULLY

SUBMITTED.

YOUR ANSWER HAS BEEN

SUCCESSFULLY SUBMITTED.

YOUR ANSWER

HAS BEEN

SUCCESSFULLY

SUBMITTED.

YOUR QUOTE REQUEST HAS BEEN

SUCCESSFULLY SUBMITTED.

OUR DOCTORS WILL GET BACK TO YOU SHORTLY!

YOUR QUOTE REQUEST

HAS BEEN

SUCCESSFULLY

SUBMITTED.

OUR DOCTORS WILL GET

BACK TO YOU SHORTLY!

YOUR THREAD HAS BEEN

SUCCESSFULLY CREATED.

HEAD OVER TO FORUM PAGE NOW

TO JOIN THE DISCUSSION

YOUR THREAD

HAS BEEN

SUCCESSFULLY

CREATED.

HEAD OVER TO THE FORUM PAGE NOW

TO JOIN THE DISCUSSION!

YOUR REVIEW HAS BEEN

SUCCESSFULLY SUBMITTED.

THANK YOU.

YOUR REVIEW

HAS BEEN

SUCCESSFULLY

SUBMITTED.

THANK YOU.

YOUR EMAIL HAS BEEN

SUCCESSFULLY SUBSCRIBED.

THANK YOU.

YOUR EMAIL

HAS BEEN

SUCCESSFULLY

SUBSCRIBED.

THANK YOU.

YOUR CONSULTATION HAS BEEN

SUCCESSFULLY SUBMITTED.

OUR DOCTORS WILL

GET BACK TO YOU SHORTLY.

YOUR CONSULTATION

HAS BEEN

SUCCESSFULLY

SUBMITTED.

OUR DOCTORS

WILL GET

TO YOU

SHORTLY.

MESSAGES TO