Request answers from expert doctors:

DxD
DxD

We will distribute this question to expert doctors, and notify you about new answers.





Is high dose Accutane more effective in preventing acne relapse?

Acne & Scars

I'm a 20 years old male. I used to have very severe acne, but now I have mild acne. My dermatologist has started me on 10 mg isotretinoin on alternate days. She informed me that Isotretinoin cannot be given at a higher dose than 40 mg. I am interested to prevent an acne relapse, and was wondering if high dose Accutane is more effective in preventing acne relapse?

DOCTOR’S ANSWER (4)

Oral isotretinoin is a very useful oral medication for treating severe acne, especially associated with scarring.

In your case, your doctor has started you on a relatively lower dose regimen of oral isotretinoin 10mg on alternate days. If this dosing regimen is working well for you in reducing acne relapses, then there is probably no need to use a higher dose regimen.  

In fact, with a higher dose, there will be more expected side effects eg dryness on the skin, lips and eyes which can be quite uncomfortable for some patients. 

Please also bear in mind that oral isotretinoin must never be taken by females who are pregnant or who are contemplating to get pregnant, as there is potential serious adverse side effects to the developing foetus.

So I would recommend you to speak to an experienced doctor in treating acne with oral isotretinoin to assess your condition and advise you further to optimise your dosing regimen.

Hope this helps!

Cheer!

Dr David Ng C H


Dr David Ng C H
MBBS, GDFM, Dip. Pract. Derm

One Face Skin & Aesthetics Clinic

1 Tras Link #02-01, Orchid Hotel, Singapore 078867


1348 views 3 Jul 2018

If your current dosing regime of 10 mg of isotretinoin on alternate days is working well, there is no need for a higher dose of Accutane.

Higher doses of Accutane are associated with more side-effects such as dryness of mucous membranes (eg lips and eyes). There is also a possibility of your liver function and cholesterol levels being affected.

I understand that you are interested to prevent an acne relapse. I recommend that you continue at your current dosage of isotretinoin especially if it gives you results without major complications. 

Hope that this helps!

Warmest regards,

Dr Justin Boey


Dr Justin Boey
MBBS

Sozo Aesthetic Clinic

1 Raffles Place #05-12/13
One Raffles Place (Shopping Mall)
Singapore 048616


1309 views 5 Jul 2018

The general consensus on the treatment of acne using oral isotretinoin has moved towards using low-dose. Not only is it safer (risks of complications and side effects- which my fellow colleagues have already covered), its efficacy has been proven to be equal to that of high dose oral isotretinoin and therefore also more economical. One example of many studies performed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037971/

I would only recommend increasing the dose of oral isotretinoin in patients with severe acne refractory to lower doses, with proper follow up of blood tests and consultation.


Hope this helps.


Cheers,

Dr David Deng


Dr David Deng
MBBS, MRCS

8 Medical Aesthetic Clinic

8 Medical Aesthetic Clinic

1 Grange Road #06-05, Orchard Building

Singapore 239693


1297 views 6 Jul 2018

No, high dose accutane does not help prevent future acne. It's actually the total accumulated dose that you need to reach that will reduce the chance of relapse, and the dosage will depend on your body weight, the control of your acne and the serverity of your acne and the presence of side effects like dryness.

Your doctor should know so ask him/her to explain to you. Hope that helps!


Dr Kelvin Chua
MBBS

SL Clinic

501 Orchard Road

#04-04 Wheelock Place

Singapore 238880


1249 views 10 Jul 2018
Not the answer you're looking for? Browse other answers tagged Acne & Scars or ask your own question now FOR FREE.
Consult Doctors. FREE.
Real Doctors, Expert Answers
Connect with Facebook Connect with Google For Doctors
By creating an account, you are indicating that you have read and accepted the DoctorxDentist Terms of Use.
Consult Doctors. FREE.
Real Doctors, Expert Answers
By creating an account, you are indicating that you have read and accepted the DoctorxDentist Terms of Use.
Registration Progress
Step 1: Indicate Topics of Interests
Step 2: Follow Relevant Doctors
Complete!
What are your interests?
Please select at least 3 interests.
NEXT
NEXT
Registration Progress
Step 1: Indicate Topics of doctors
Step 2: Follow Relevant Doctors
Complete!
Follow your favourite doctors
We found some doctors you may like. Click continue to follow them.
CONTINUE
CONTINUE
Consult Doctors. FREE.
Real Doctors, Expert Answers
Continue with Facebook Continue with Google

or

Disclaimer: Any answers provided are for general informational purposes only and is not a substitute for professional medical advice. If you think you may have a medical emergency, call your doctor immediately. Always seek the advice of your doctor before starting or changing treatment.

Continue with Facebook Continue with Google

Disclaimer: Any answers provided are for general informational purposes only and is not a substitute for professional medical advice. If you think you may have a medical emergency, call your doctor immediately. Always seek the advice of your doctor before starting or changing treatment.

YOUR QUESTION HAS BEEN

SUCCESSFULLY SUBMITTED.

YOUR QUESTION

HAS BEEN

SUCCESSFULLY

SUBMITTED.

YOUR ANSWER HAS BEEN

SUCCESSFULLY SUBMITTED.

YOUR ANSWER

HAS BEEN

SUCCESSFULLY

SUBMITTED.

YOUR QUOTE REQUEST HAS BEEN

SUCCESSFULLY SUBMITTED.

OUR DOCTORS WILL GET BACK TO YOU SHORTLY!

YOUR QUOTE REQUEST

HAS BEEN

SUCCESSFULLY

SUBMITTED.

OUR DOCTORS WILL GET

BACK TO YOU SHORTLY!

YOUR THREAD HAS BEEN

SUCCESSFULLY CREATED.

HEAD OVER TO FORUM PAGE NOW

TO JOIN THE DISCUSSION

YOUR THREAD

HAS BEEN

SUCCESSFULLY

CREATED.

HEAD OVER TO THE FORUM PAGE NOW

TO JOIN THE DISCUSSION!

YOUR REVIEW HAS BEEN

SUCCESSFULLY SUBMITTED.

THANK YOU.

YOUR REVIEW

HAS BEEN

SUCCESSFULLY

SUBMITTED.

THANK YOU.

YOUR EMAIL HAS BEEN

SUCCESSFULLY SUBSCRIBED.

THANK YOU.

YOUR EMAIL

HAS BEEN

SUCCESSFULLY

SUBSCRIBED.

THANK YOU.

YOUR CONSULTATION HAS BEEN

SUCCESSFULLY SUBMITTED.

OUR DOCTORS WILL

GET BACK TO YOU SHORTLY.

YOUR CONSULTATION

HAS BEEN

SUCCESSFULLY

SUBMITTED.

OUR DOCTORS

WILL GET

TO YOU

SHORTLY.

MESSAGES TO