The CO2 laser is able to remove syringomas. Studies show this procedure to be effective and safe with minimal side effects. There are other techniques such as use of TCA (trichloroacetic acid) and radiofrequency ablation as well.
Combination therapy of the above has yielded good success in general in terms of complete ablation and good cosmetic results without significant side effects. However, the recurrence rates are high with any treatment modality including laser ablation.
I prefer to use the CO2 laser in the ablative mode for treating syringomas. Fractional CO2 laser generally requires multiple passes and consecutive treatments (ie more than 2 times as per your question) at one-month intervals to achieve the same results (International Journal of Women’s Dermatology, 2017).
Hope this helps!
Regards,
Dr. Joanna Chan