What is the difference between PN Cell Regation and Rejuran Healer?Aesthetic Medicine Skin, Hair & Nails
I understand that both PN Cell Regation and Rejuran Healer are used for cell regeneration and rejuvenation. I would like to find out what is the difference between these 2 in terms of active ingredients, efficacy, and safety?
Both PN Cell Regation and Rejuran are different brands of Polynucleotides. Both are manufactured from the male salmon fish milt but the extraction and purification processes may differ slightly.
Both have clinical studies/papers to back up their claims in skin rejuvenation. However, Rejuran has been on the market longer and has better track record based on usage.
Thank you for your question.
What is the difference between PN Cell Regation and Rejuran Healer?
Rejuran Healer and PN Cell Regation are different brands of injectible polydeoxyribonucleotide (PDRN) containing skin fillers from Korea.
PDRN has been showed in multiple studies to accelerate wound healing and to have anti-inflammatory and angiogenic effects. In a clinical trial, PDRN also improved elasticity and collagen composition, skin surface roughness and wrinkle depth.
Originally, PDRN was extracted from human placenta but due to ethical concerns and difficulties in production, it is now extracted from salmon reproductive cells.
In terms of active ingredients, PN Cell Regation is extracted from Oncorhynchus masou (masu salmon) whereas Rejuran Healer appears to be extracted from Oncorhynchus keta (chum salmon). PN Cell Regation also contains hyaluronic acid in addition to just PDRN. There haven't been any published studies comparing the efficacy and safety of these two sources of PDRN. However, a study comparing wound healing effects between Oncorhynchus keta-derived PDRN and Oncorhynchus mykiss-derived PDRN found that they have comparable effects.
PN Cell Regation is relatively new on the Singapore market while Rejuran Healer has been distributed locally for some time already. Thus, Rejuran is more common.
My personal take is that there is unlikely to be much difference between the two.
Hope this helps!
Dr Wan Chee Kwang
1. Pak et al. A Phase III, Randomized, Double-Blind, Matched-Pairs, Active-Controlled Clinical Trial and Preclinical Animal Study to Compare the Durability, Efficacy and Safety between Polynucleotide Filler and Hyaluronic Acid Filler in the Correction of Crow's Feet: A New Concept of Regenerative Filler. J Korean Med Sci. 2014 Nov; 29(Suppl 3): S201–S209.
2. Shin et al. The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report. Ann Rehabil Med. 2018 Aug; 42(4): 630–633.
3. Kim et al. Polydeoxyribonucleotide Improves Peripheral Tissue Oxygenation and Accelerates Angiogenesis in Diabetic Foot Ulcers. Arch Plast Surg. 2017 Nov; 44(6): 482–489.
4. Lee et al. Comparison of wound healing effects between Oncorhynchus keta-derived polydeoxyribonucleotide (PDRN) and Oncorhynchus mykiss-derived PDRN. Arch Craniofac Surg. 2018 Mar;19(1):20-34.