It is not uncommon to develop discontinuation symptoms following cessation of antidepressant treatment. The term 'discontinuation symptoms' is preferred in your scenario as you describe symptoms experienced on stopping prescribed drugs that are not drugs of dependence. Discontinuations symptoms include irritability, headache, nausea, vomiting, sweating, pins and needles sensation, unsteady of gait, dizziness exacerbated by movement, insomnia, increased dreaming and flu-like symptoms.
The onset of symptoms is usually within 5 days of stopping antidepressant treatment. When taken continuously for 6 weeks or longer, antidepressants should not be stopped suddenly unless a serious side effect has developed.
Generally, antidepressant therapy should be discontinued over at least a 4-week period. This is not required with fluoxetine which has a long half life and is therefore likely to remain in the body over a long time. Discontinuation symptoms can occur after missed doses if the antidepressant prescribed has a short half -life. (e.g, paroxetine, venlafaxine).
In most cases, the symptoms are mild and will pass in a few days. If symptoms are severe, what I would do is to re-introduce the original antidepressant (or another with a longer half life from the same class) and taper gradually while monitoring for symptoms.
For persons suffering from a first episode of major depression, it is advisable to take the antidepressant for about 9 months or so. Do discuss with your doctor first before you stop the antidepressant. If the course of treatment is too short, there is a high chance that the depressive symptoms will come back.
Cheers! Take good care and work closely with a doctor whom you trust.
Dr Ng Beng Yeong
