How can I manage the possible complications of applying tretinoin cream while on doxycycline?

One of the more common issues with using tretinoin cream for acne control is skin irritation. Skin irritation is most common during the first few weeks of treatment. To manage this, consider the following strategies:

1. Applying a lesser amount of tretinoin cream
2. Use the tretinoin cream less frequently: 2-3 times weekly instead of nightly
3. Apply a mild moisturizer as a base before applying the tretinoin 15 minutes later

The above strategies, alone or in combination will usually help to reduce the skin irritation from tretinoin during the initial period of starting the application of tretinoin cream and get your skin used to the medication.