The problem you are facing could be due to a combination of environmental, hormonal or lifestyle factors. These need to be analysed carefully to come up with a tailored approach. Diet, stress, hormonal imbalances and skincare habits are some common issues.
Modifying your skincare regimen should already help your clogged comedones very much. Proper skincare using the correct cleanser, toner, serums and moisturiser can all affect the severity of your comedones. Using hyaluronic acid at night is a good step to keep the skin moist so that there is less sebum secretion and less clogged pores, but it doesn't seem to be enough in your case.
Certain skin topicals like benzoyl peroxide, fruit acids and retinoids may help, but which type to start depends on the skin type, and proper advice from a doctor on how to use it. If you are keen to try the OTC formulations without consulting a doctor, a doctor has offered some good advice here regarding Retin use.
Lastly, certain medical treatments may hasten your improvement. The right type of chemical peels and lasers are extremely useful for removing clogged pores and preventing excess sebum secretion (hence helping solve the root cause).
This article may provide a good idea regarding the various treatments available and which ones can really help comedones/pores.
Hope this helps!
