GGT or Gama-Glutamyl-Transferase is one of a group of serum enzymes listed under the Liver Function Test. Just like the other liver enzymes, GGT elevation is found in many conditions and they do not necessarily indicate significant liver diseases.
A well-known cause of predominantly GGT elevation is alcohol consumption or the use of medicine to control seizure or fits. The GGT levels under such circumstances may normalise once these stimulants are removed without much long term effects on the liver.
Having said that, concurrent GGT elevation with the other liver enzymes or bilirubin may indicate serious bile duct or liver diseases. It is important to note that the serum GGT level does correlate well with disease severity. Serious diseases may present with only a mild level of GGT elevation. As such, it is always prudent to consider undergoing proper evaluation by a doctor if you notice persistent GGT elevation in your blood samples.
- Dr Quan
