How safe is Rejuran and who is suitable for it?
I would like to understand how safe Rejuran is? Some websites state that the long term effects of Rejuran is not well documented, and it is not US FDA approved. In addition, who is and isn’t suitable for Rejuran? For example, are people with acne prone skin or closed comedones suitable for Rejuran?
Rejuran is one of the newer Korean beauty craze that has hit Singapore, known especially among those familiar with aesthetic treatments. The representation of the glowy, flawless complexion of Korean beauties has inspired many to follow their beauty regimes, and Rejuran is one of the new items to add to the to-do list.
Though popularized by the Koreans, it has actually been used in other countries, like Europe, since the 2000s (Plinest, manufactured by an Italian bio-pharmaceutical company), with clinical research stretching even to the past 40 years. The principle ingredient is polynucleotide (PN) derived from salmon germ cell, which essentially is the building block of our DNA. The main effects are anti-inflammatory and regenerative. As such, PN has been used in other aspects of medicine, such as in orthopedics, gynaecology and dermatology.
Yes, I would agree with you that long-term safety in aesthetic medicine has not been completely established, but studies so far have been encouraging without any major side effects. Adverse effects have mainly been limited to minor temporary ones, like mild pain and bruising. Currently, Rejuran is Korean-FDA and HSA-approved.
If your main problem is acne-prone skin and closed comedones, I would not personally recommend Rejuran as the first-line of treatment. Depending on the severity of the acne, medicated creams or oral medications, or even laser treatments would be preferable. That being said, one of the effects of Rejuran is sebum reduction, balancing the oil and moisture of the skin. If you have tried the main acne treatments with adverse effects, Rejuran can be considered as one of the alternatives. It can also be combined with botox to further reduce sebum and pore size, or combined with steroids for active acne lesions.
Generally, Rejuran can be done for most skin types. So far, I have only turned away those who report a severe allergy to seafood. For those blessed with fairly good skin, Rejuran can be used as a preventative strategy to slow down the manifestations of ageing skin. Used as a recovery treatment, Rejuran can be beneficial for those with dry skin, thinning skin, open pores, fine lines, uneven skin tone.
However, results do require patience as there are some who don't see a visual improvement after a single session. Regeneration and healing at the cellular level takes time, and 3-4 sessions, each spaced 3-4 weeks apart are recommended for an optimal result. The other thing to consider is the downtime. Be it injected manually or with machines, there are small needle marks and even wheals/ bumps which are more obvious for the first day or so. By the 2nd or 3rd day, most can return to normal activities if some make-up coverage if preferred.
Hope this has helped answer your queries.